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Estrogen receptor beta and truncated variants enhance the expression of transfected MMP-1 promoter constructs in response to specific mechanical loading

BACKGROUND: Joint diseases such as osteoarthritis (OA) predominantly afflict post-menopausal women, suggesting a pertinent role for female hormones. Estrogen receptor beta (ER-β) has been detected in connective tissues of the knee joint suggesting that these tissues are responsive to the hormone est...

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Detalles Bibliográficos
Autores principales: Thaler, John D, Achari, Yamini, Lu, Ting, Shrive, Nigel G, Hart, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306124/
https://www.ncbi.nlm.nih.gov/pubmed/25625008
http://dx.doi.org/10.1186/s13293-014-0014-6