Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation

Tau hyperphosphorylation is thought to underlie tauopathy. Working in a Drosophila tauopathy model expressing a human Tau mutant (hTauR406W, or Tau*), we show that zinc contributes to the development of Tau toxicity through two independent actions: by increasing Tau phosphorylation and, more signifi...

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Detalles Bibliográficos
Autores principales: Huang, Yunpeng, Wu, Zhihao, Cao, Yu, Lang, Minglin, Lu, Bingwei, Zhou, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306234/
https://www.ncbi.nlm.nih.gov/pubmed/25066125
http://dx.doi.org/10.1016/j.celrep.2014.06.047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306234/
https://www.ncbi.nlm.nih.gov/pubmed/25066125
http://dx.doi.org/10.1016/j.celrep.2014.06.047

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