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Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
Tau hyperphosphorylation is thought to underlie tauopathy. Working in a Drosophila tauopathy model expressing a human Tau mutant (hTauR406W, or Tau*), we show that zinc contributes to the development of Tau toxicity through two independent actions: by increasing Tau phosphorylation and, more signifi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306234/ https://www.ncbi.nlm.nih.gov/pubmed/25066125 http://dx.doi.org/10.1016/j.celrep.2014.06.047 |