Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ(8)-Tetrahydrocannabinols

[Image: see text] We recently reported on a controlled deactivation/detoxification approach for obtaining cannabinoids with improved druggability. Our design incorporates a metabolically labile ester group at strategic positions within the THC structure. We have now synthesized a series of (−)-Δ(8)-...

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Detalles Bibliográficos
Autores principales: Nikas, Spyros P., Sharma, Rishi, Paronis, Carol A., Kulkarni, Shashank, Thakur, Ganesh A., Hurst, Dow, Wood, JodiAnne T., Gifford, Roger S., Rajarshi, Girija, Liu, Yingpeng, Raghav, Jimit Girish, Guo, Jason Jianxin, Järbe, Torbjörn U.C., Reggio, Patricia H., Bergman, Jack, Makriyannis, Alexandros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306527/
https://www.ncbi.nlm.nih.gov/pubmed/25470070
http://dx.doi.org/10.1021/jm501165d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306527/
https://www.ncbi.nlm.nih.gov/pubmed/25470070
http://dx.doi.org/10.1021/jm501165d

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