Development of Highly Selective Kv1.3-Blocking Peptides Based on the Sea Anemone Peptide ShK

ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186, which is currently in Phase 1b-2a clinical trials...

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Detalles Bibliográficos
Autores principales: Pennington, Michael W., Chang, Shih Chieh, Chauhan, Satendra, Huq, Redwan, Tajhya, Rajeev B., Chhabra, Sandeep, Norton, Raymond S., Beeton, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306950/
https://www.ncbi.nlm.nih.gov/pubmed/25603346
http://dx.doi.org/10.3390/md13010529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306950/
https://www.ncbi.nlm.nih.gov/pubmed/25603346
http://dx.doi.org/10.3390/md13010529

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