Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles

Three JNK isoforms, JNK1, JNK2, and JNK3 have been reported and unique biological function has been ascribed to each. It is unknown if selective inhibition of these isoforms would confer therapeutic or safety benefit. To probe JNK isoform function we designed JNK2/3 inhibitors that have >30-fold...

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Detalles Bibliográficos
Autores principales: Park, HaJeung, Iqbal, Sarah, Hernandez, Pamela, Mora, Rudy, Zheng, Ke, Feng, Yangbo, LoGrasso, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306959/
https://www.ncbi.nlm.nih.gov/pubmed/25623238
http://dx.doi.org/10.1038/srep08047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306959/
https://www.ncbi.nlm.nih.gov/pubmed/25623238
http://dx.doi.org/10.1038/srep08047

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