Connexin 43 Suppresses Tumor Angiogenesis by Down-Regulation of Vascular Endothelial Growth Factor via Hypoxic-Induced Factor-1α

Previous work showed that connexin 43 (Cx43) reduced the expression of hypoxic-induced factor-1α (HIF-1α) in astrocytes. HIF-1α is a master transcription factor for angiogenesis in tumor. Angiogenesis is essential for tumor progression. Here, we investigated the role of Cx43 in vascular endothelial...

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Detalles Bibliográficos
Autores principales: Wang, Wei-Kuang, Chen, Man-Chin, Leong, Hon-Fai, Kuo, Yu-Liang, Kuo, Chun-Yu, Lee, Che-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307255/
https://www.ncbi.nlm.nih.gov/pubmed/25548899
http://dx.doi.org/10.3390/ijms16010439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307255/
https://www.ncbi.nlm.nih.gov/pubmed/25548899
http://dx.doi.org/10.3390/ijms16010439

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