Acetic Acid Can Catalyze Succinimide Formation from Aspartic Acid Residues by a Concerted Bond Reorganization Mechanism: A Computational Study

Succinimide formation from aspartic acid (Asp) residues is a concern in the formulation of protein drugs. Based on density functional theory calculations using Ace-Asp-Nme (Ace = acetyl, Nme = NHMe) as a model compound, we propose the possibility that acetic acid (AA), which is often used in protein...

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Detalles Bibliográficos
Autores principales: Takahashi, Ohgi, Kirikoshi, Ryota, Manabe, Noriyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307323/
https://www.ncbi.nlm.nih.gov/pubmed/25588215
http://dx.doi.org/10.3390/ijms16011613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307323/
https://www.ncbi.nlm.nih.gov/pubmed/25588215
http://dx.doi.org/10.3390/ijms16011613

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