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Enzymatic cleavage of histone H3: a new consideration when measuring histone modifications in human samples

Histone modifications are increasingly being used as biomarkers of cancer prognosis and survival. However, we identified a cleavage product of histone H3 in human peripheral blood mononuclear cells, which interferes with measures of certain H3 modifications. Therefore, the potential for enzymatic cl...

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Detalles Bibliográficos
Autores principales: Howe, Caitlin G, Gamble, Mary V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307743/
https://www.ncbi.nlm.nih.gov/pubmed/25628766
http://dx.doi.org/10.1186/s13148-014-0041-5