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Strategies to stabilize compact folding and minimize aggregation of antibody-based fragments
Monoclonal antibodies (mAbs) have proven to be useful for development of new therapeutic drugs and diagnostic techniques. To overcome the difficulties posed by their complex structure and folding, reduce undesired immunogenicity, and improve pharmacokinetic properties, a plethora of different Ab fra...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307952/ https://www.ncbi.nlm.nih.gov/pubmed/25635232 http://dx.doi.org/10.4236/abb.2013.44A011 |