Tyrosine Kinase Inhibition Regulates Early Systemic Immune Changes and Modulates the Neuroimmune Response in α-Synucleinopathy

OBJECTIVES: Neuro-inflammation is common in α-Synucleinopathies and Tauopathies; and evidence suggests a link between the tyrosine kinase Abl and neurodegeneration. Abl upregulates α-Synuclein and promotes Tau hyper-phosphorylation (p-Tau), while Abl inhibitors facilitate autophagic clearance. METHO...

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Detalles Bibliográficos
Autores principales: Hebron, Michaeline L., Lonskaya, Irina, Olopade, Paul, Selby, Sandra T., Pagan, Fernando, Moussa, Charbel E-H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308054/
https://www.ncbi.nlm.nih.gov/pubmed/25635231
http://dx.doi.org/10.4172/2155-9899.1000259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308054/
https://www.ncbi.nlm.nih.gov/pubmed/25635231
http://dx.doi.org/10.4172/2155-9899.1000259

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