Cathepsin Inhibition-Induced Lysosomal Dysfunction Enhances Pancreatic Beta-Cell Apoptosis in High Glucose

Autophagy is a lysosomal degradative pathway that plays an important role in maintaining cellular homeostasis. We previously showed that the inhibition of autophagy causes pancreatic β-cell apoptosis, suggesting that autophagy is a protective mechanism for the survival of pancreatic β-cells. The cur...

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Detalles Bibliográficos
Autores principales: Jung, Minjeong, Lee, Jaemeun, Seo, Hye-Young, Lim, Ji Sun, Kim, Eun-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308077/
https://www.ncbi.nlm.nih.gov/pubmed/25625842
http://dx.doi.org/10.1371/journal.pone.0116972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308077/
https://www.ncbi.nlm.nih.gov/pubmed/25625842
http://dx.doi.org/10.1371/journal.pone.0116972

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