Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1

The corticotropin releasing factors receptor-1 and receptor-2 (CRF(1)R and CRF(2)R) are therapeutic targets for treating neurological diseases. Antagonists targeting CRF(1)R have been developed for the potential treatment of anxiety disorders and alcohol addiction. It has been found that antagonists...

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Detalles Bibliográficos
Autores principales: Sun, Xianqiang, Cheng, Jianxin, Wang, Xu, Tang, Yun, Ågren, Hans, Tu, Yaoquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308710/
https://www.ncbi.nlm.nih.gov/pubmed/25628267
http://dx.doi.org/10.1038/srep08066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308710/
https://www.ncbi.nlm.nih.gov/pubmed/25628267
http://dx.doi.org/10.1038/srep08066

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