Role of the Active Site Guanine in the glmS Ribozyme Self-Cleavage Mechanism: Quantum Mechanical/Molecular Mechanical Free Energy Simulations

[Image: see text] The glmS ribozyme catalyzes a self-cleavage reaction at the phosphodiester bond between residues A-1 and G1. This reaction is thought to occur by an acid–base mechanism involving the glucosamine-6-phosphate cofactor and G40 residue. Herein quantum mechanical/molecular mechanical fr...

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Detalles Bibliográficos
Autores principales: Zhang, Sixue, Ganguly, Abir, Goyal, Puja, Bingaman, Jamie L., Bevilacqua, Philip C., Hammes-Schiffer, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308743/
https://www.ncbi.nlm.nih.gov/pubmed/25526516
http://dx.doi.org/10.1021/ja510387y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308743/
https://www.ncbi.nlm.nih.gov/pubmed/25526516
http://dx.doi.org/10.1021/ja510387y

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