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Three-dimensional pharmacophore screening for fentanyl derivatives☆
Fentanyl is a highly selective μ-opioid receptor agonist with high analgesic activity. Three-dimensional pharmacophore models were built from a set of 50 fentanyl derivatives. These were employed to elucidate ligand-receptor interactions using information derived only from the ligand structure to id...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308790/ https://www.ncbi.nlm.nih.gov/pubmed/25657673 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.18.006 |