Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signaling

Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A inactivation is not sufficient for tumor formation, but requires concurrent activation of the phosphoinositide 3-kinase catal...

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Detalles Bibliográficos
Autores principales: Chandler, Ronald L., Damrauer, Jeffrey S., Raab, Jesse R., Schisler, Jonathan C., Wilkerson, Matthew D., Didion, John P., Starmer, Joshua, Serber, Daniel, Yee, Della, Xiong, Jessie, Darr, David B., Pardo-Manuel de Villena, Fernando, Kim, William Y., Magnuson, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308813/
https://www.ncbi.nlm.nih.gov/pubmed/25625625
http://dx.doi.org/10.1038/ncomms7118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308813/
https://www.ncbi.nlm.nih.gov/pubmed/25625625
http://dx.doi.org/10.1038/ncomms7118

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