Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction

BACKGROUND: The Y-box binding protein 1 (YB-1) possesses pleiotropic functions through its interactions with various cellular proteins, and its high expression levels make it a potential useful prognostic biomarker for cancer cells. Eukaryotic DNA topoisomerases, such as DNA topoisomerase 1 (TOPO1)...

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Detalles Bibliográficos
Autores principales: Wu, Ying, Wang, Ke-yong, Li, Zhi, Liu, Yun-peng, Izumi, Hiroto, Uramoto, Hidetaka, Nakayama, Yoshifumi, Ito, Ken-ichi, Kohno, Kimitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308875/
https://www.ncbi.nlm.nih.gov/pubmed/25539742
http://dx.doi.org/10.1186/s13046-014-0112-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308875/
https://www.ncbi.nlm.nih.gov/pubmed/25539742
http://dx.doi.org/10.1186/s13046-014-0112-7

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