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Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction
BACKGROUND: The Y-box binding protein 1 (YB-1) possesses pleiotropic functions through its interactions with various cellular proteins, and its high expression levels make it a potential useful prognostic biomarker for cancer cells. Eukaryotic DNA topoisomerases, such as DNA topoisomerase 1 (TOPO1)...
Autores principales: | Wu, Ying, Wang, Ke-yong, Li, Zhi, Liu, Yun-peng, Izumi, Hiroto, Uramoto, Hidetaka, Nakayama, Yoshifumi, Ito, Ken-ichi, Kohno, Kimitoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308875/ https://www.ncbi.nlm.nih.gov/pubmed/25539742 http://dx.doi.org/10.1186/s13046-014-0112-7 |
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