Association of BRCA1/2defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes

INTRODUCTION: Homologous recombination (HR) DNA repair is of clinical relevance in breast cancer. Three DNA-based homologous recombination deficiency (HRD) scores (HRD-loss of heterozygosity score (LOH), HRD-telomeric allelic imbalance score (TAI), and HRD-large-scale state transition score (LST)) h...

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Detalles Bibliográficos
Autores principales: Timms, Kirsten M, Abkevich, Victor, Hughes, Elisha, Neff, Chris, Reid, Julia, Morris, Brian, Kalva, Saritha, Potter, Jennifer, Tran, Thanh V, Chen, Jian, Iliev, Diana, Sangale, Zaina, Tikishvili, Eliso, Perry, Michael, Zharkikh, Andrey, Gutin, Alexander, Lanchbury, Jerry S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308910/
https://www.ncbi.nlm.nih.gov/pubmed/25475740
http://dx.doi.org/10.1186/s13058-014-0475-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308910/
https://www.ncbi.nlm.nih.gov/pubmed/25475740
http://dx.doi.org/10.1186/s13058-014-0475-x

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