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Calpain‐Dependent Cleavage of Junctophilin‐2 and T‐Tubule Remodeling in a Mouse Model of Reversible Heart Failure
BACKGROUND: A highly organized transverse tubule (T‐tubule) network is necessary for efficient Ca(2+)‐induced Ca(2+) release and synchronized contraction of ventricular myocytes. Increasing evidence suggests that T‐tubule remodeling due to junctophilin‐2 (JP‐2) downregulation plays a critical role i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309042/ https://www.ncbi.nlm.nih.gov/pubmed/24958777 http://dx.doi.org/10.1161/JAHA.113.000527 |