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Calpain‐Dependent Cleavage of Junctophilin‐2 and T‐Tubule Remodeling in a Mouse Model of Reversible Heart Failure

BACKGROUND: A highly organized transverse tubule (T‐tubule) network is necessary for efficient Ca(2+)‐induced Ca(2+) release and synchronized contraction of ventricular myocytes. Increasing evidence suggests that T‐tubule remodeling due to junctophilin‐2 (JP‐2) downregulation plays a critical role i...

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Detalles Bibliográficos
Autores principales:	Wu, Chia‐Yen C., Chen, Biyi, Jiang, Ya‐Ping, Jia, Zhiheng, Martin, Dwight W., Liu, Shengnan, Entcheva, Emilia, Song, Long‐Sheng, Lin, Richard Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309042/ https://www.ncbi.nlm.nih.gov/pubmed/24958777 http://dx.doi.org/10.1161/JAHA.113.000527

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