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Smooth Muscle Specific Rac1 Deficiency Induces Hypertension by Preventing p116(RIP)(3)‐Dependent RhoA Inhibition
BACKGROUND: Increasing evidence implicates overactivation of RhoA as a critical component of the pathogenesis of hypertension. Although a substantial body of work has established that Rac1 functions antagonize RhoA in a broad range of physiological processes, the role of Rac1 in the regulation of va...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309079/ https://www.ncbi.nlm.nih.gov/pubmed/24938713 http://dx.doi.org/10.1161/JAHA.114.000852 |