Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure

Loss of sensory hair cells from exposure to certain licit drugs (e.g., aminoglycoside antibiotics, platinum-based chemotherapy agents) can result in permanent hearing loss. Here we ask if allosteric activation of the hepatocyte growth factor (HGF) cascade via Dihexa, a small molecule drug candidate,...

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Detalles Bibliográficos
Autores principales: Uribe, Phillip M., Kawas, Leen H., Harding, Joseph W., Coffin, Allison B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309183/
https://www.ncbi.nlm.nih.gov/pubmed/25674052
http://dx.doi.org/10.3389/fncel.2015.00003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309183/
https://www.ncbi.nlm.nih.gov/pubmed/25674052
http://dx.doi.org/10.3389/fncel.2015.00003

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