Elevated Estrogen Receptor-α in VHL-Deficient Condition Induces Microtubule Organizing Center Amplification via Disruption of BRCA1/Rad51 Interaction

Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate to angiogenesis step after tumor mass formation. Co...

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Detalles Bibliográficos
Autores principales: Jung, Youn-Sang, Chun, Ho-Young, Yoon, Min-Ho, Park, Bum-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309251/
https://www.ncbi.nlm.nih.gov/pubmed/25499220
http://dx.doi.org/10.1016/j.neo.2014.09.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309251/
https://www.ncbi.nlm.nih.gov/pubmed/25499220
http://dx.doi.org/10.1016/j.neo.2014.09.013

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