Evolution of BCR/ABL Gene Mutation in CML Is Time Dependent and Dependent on the Pressure Exerted by Tyrosine Kinase Inhibitor

BACKGROUND: Mutations in the ABL kinase domain and SH3-SH2 domain of the BCR/ABL gene and amplification of the Philadelphia chromosome are the two important BCR/ABL dependent mechanisms of imatinib resistance. Here, we intended to study the role played by TKI, imatinib, in selection of gene mutation...

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Detalles Bibliográficos
Autores principales: Vaidya, Shantashri, Vundinti, Babu Rao, Shanmukhaiah, Chandrakala, Chakrabarti, Prantar, Ghosh, Kanjaksha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309587/
https://www.ncbi.nlm.nih.gov/pubmed/25629972
http://dx.doi.org/10.1371/journal.pone.0114828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309587/
https://www.ncbi.nlm.nih.gov/pubmed/25629972
http://dx.doi.org/10.1371/journal.pone.0114828

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