The Extracellular Loop 2 (ECL2) of the Human Histamine H(4) Receptor Substantially Contributes to Ligand Binding and Constitutive Activity

In contrast to the corresponding mouse and rat orthologs, the human histamine H(4) receptor (hH(4)R) shows extraordinarily high constitutive activity. In the extracellular loop (ECL), replacement of F169 by V as in the mouse H(4)R significantly reduced constitutive activity. Stabilization of the ina...

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Detalles Bibliográficos
Autores principales: Wifling, David, Bernhardt, Günther, Dove, Stefan, Buschauer, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309601/
https://www.ncbi.nlm.nih.gov/pubmed/25629160
http://dx.doi.org/10.1371/journal.pone.0117185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309601/
https://www.ncbi.nlm.nih.gov/pubmed/25629160
http://dx.doi.org/10.1371/journal.pone.0117185

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