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Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer()()
Heparanase (HPSE) is the dominant mammalian endoglycosidase and important tumorigenic, angiogenic, and pro-metastatic molecule. Highest levels of HPSE activity have been consistently detected in cells possessing highest propensities to colonize the brain, emphasizing the therapeutic potential for ta...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Neoplasia Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309682/ https://www.ncbi.nlm.nih.gov/pubmed/25622903 http://dx.doi.org/10.1016/j.neo.2014.11.007 |