Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization

Our recent study showed that SAG/RBX2 E3 ubiquitin ligase regulates apoptosis and vasculogenesis by promoting degradation of NOXA and NF1, and co-operates with Kras to promote lung tumorigenesis by activating NFκB and mTOR pathways via targeted degradation of tumor suppressive substrates including I...

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Detalles Bibliográficos
Autores principales: Tan, Mingjia, Li, Hua, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309684/
https://www.ncbi.nlm.nih.gov/pubmed/25622904
http://dx.doi.org/10.1016/j.neo.2014.11.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309684/
https://www.ncbi.nlm.nih.gov/pubmed/25622904
http://dx.doi.org/10.1016/j.neo.2014.11.008

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