Epalrestat increases glutathione, thioredoxin, and heme oxygenase-1 by stimulating Nrf2 pathway in endothelial cells

Epalrestat (EPS) is the only aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. Recently, we found that EPS at near-plasma concentration increases the intracellular levels of glutathione (GSH) in rat Schwann cells. GSH plays a crucial role in protecting...

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Detalles Bibliográficos
Autores principales: Yama, Kaori, Sato, Keisuke, Abe, Natsuki, Murao, Yu, Tatsunami, Ryosuke, Tampo, Yoshiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309844/
https://www.ncbi.nlm.nih.gov/pubmed/25529839
http://dx.doi.org/10.1016/j.redox.2014.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309844/
https://www.ncbi.nlm.nih.gov/pubmed/25529839
http://dx.doi.org/10.1016/j.redox.2014.12.002

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