Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer

Inhibition of glycolysis using 2-deoxy-d-glucose (2DG, 20 mM, 24–48 h) combined with inhibition of the pentose cycle using dehydroepiandrosterone (DHEA, 300 µM, 24–48 h) increased clonogenic cell killing in both human prostate (PC-3 and DU145) and human breast (MDA-MB231) cancer cells via a mechanis...

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Detalles Bibliográficos
Autores principales: Li, Ling, Fath, Melissa A., Scarbrough, Peter M., Watson, Walter H., Spitz, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309850/
https://www.ncbi.nlm.nih.gov/pubmed/25560241
http://dx.doi.org/10.1016/j.redox.2014.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309850/
https://www.ncbi.nlm.nih.gov/pubmed/25560241
http://dx.doi.org/10.1016/j.redox.2014.12.001

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