A novel role for 12/15-lipoxygenase in regulating autophagy

12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron dense material, indicating defects in autophagy or membrane pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Alwena H., Hammond, Victoria J., Sakoh-Nakatogawa, Machiko, Ohsumi, Yoshinori, Thomas, Christopher P., Blanchet, Fabien, Piguet, Vincent, Kiselyov, Kirill, O’Donnell, Valerie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309860/
https://www.ncbi.nlm.nih.gov/pubmed/25498966
http://dx.doi.org/10.1016/j.redox.2014.11.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309860/
https://www.ncbi.nlm.nih.gov/pubmed/25498966
http://dx.doi.org/10.1016/j.redox.2014.11.005

Ejemplares similares