Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae

Several pathological mutations have been identified in human POLG gene, encoding for the catalytic subunit of Pol γ, the solely mitochondrial replicase in animals and fungi. However, little is known regarding non-pathological polymorphisms found in this gene. Here we studied, in the yeast model Sacc...

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Detalles Bibliográficos
Autores principales: Baruffini, Enrico, Ferrari, Jessica, Dallabona, Cristina, Donnini, Claudia, Lodi, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309887/
https://www.ncbi.nlm.nih.gov/pubmed/25462018
http://dx.doi.org/10.1016/j.mito.2014.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309887/
https://www.ncbi.nlm.nih.gov/pubmed/25462018
http://dx.doi.org/10.1016/j.mito.2014.11.003

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