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A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane

Hyperpolarization-activated cyclic nucleotide-gated 1 (HCN1) channels carry I(h), which contributes to neuronal excitability and signal transmission in the nervous system. Controlling the trafficking of HCN1 is an important aspect of its regulation, yet the details of this process are poorly underst...

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Detalles Bibliográficos
Autores principales: Pan, Yuan, Laird, Joseph G., Yamaguchi, David M., Baker, Sheila A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309907/
https://www.ncbi.nlm.nih.gov/pubmed/25142030
http://dx.doi.org/10.1007/s00018-014-1705-1