Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

BACKGROUND: Alzheimer’s disease (AD) is a multifactorial disorder associated with the accumulation of soluble forms of beta-amyloid (Aβ) and its subsequent deposition into plaques. One of the major contributors to neuronal death is chronic and uncontrolled inflammatory activation of microglial cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Malm, Tarja, Mariani, Monica, Donovan, Lauren J, Neilson, Lee, Landreth, Gary E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310027/
https://www.ncbi.nlm.nih.gov/pubmed/25592770
http://dx.doi.org/10.1186/s12974-014-0229-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310027/
https://www.ncbi.nlm.nih.gov/pubmed/25592770
http://dx.doi.org/10.1186/s12974-014-0229-9

Ejemplares similares