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Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

BACKGROUND: Alzheimer’s disease (AD) is a multifactorial disorder associated with the accumulation of soluble forms of beta-amyloid (Aβ) and its subsequent deposition into plaques. One of the major contributors to neuronal death is chronic and uncontrolled inflammatory activation of microglial cells...

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Detalles Bibliográficos
Autores principales:	Malm, Tarja, Mariani, Monica, Donovan, Lauren J, Neilson, Lee, Landreth, Gary E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310027/ https://www.ncbi.nlm.nih.gov/pubmed/25592770 http://dx.doi.org/10.1186/s12974-014-0229-9

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