FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach

Non-steroidal anti-inflammatory drugs (NSAIDs) are worldwide used drugs for analgesic, antipyretic, and anti-inflammatory therapeutics. However, NSAIDs often cause several serious liver injuries, such as drug-induced liver injury (DILI), and the molecular mechanisms of DILI have not been clearly elu...

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Detalles Bibliográficos
Autores principales: Lu, Weiqiang, Cheng, Feixiong, Jiang, Jing, Zhang, Chen, Deng, Xiaokang, Xu, Zhongyu, Zou, Shien, Shen, Xu, Tang, Yun, Huang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310094/
https://www.ncbi.nlm.nih.gov/pubmed/25631039
http://dx.doi.org/10.1038/srep08114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310094/
https://www.ncbi.nlm.nih.gov/pubmed/25631039
http://dx.doi.org/10.1038/srep08114

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