The Direct Assignment Option as a Modular Design Component: An Example for the Setting of Two Predefined Subgroups

Background. A phase II design with an option for direct assignment (stop randomization and assign all patients to experimental treatment based on interim analysis, IA) for a predefined subgroup was previously proposed. Here, we illustrate the modularity of the direct assignment option by applying it...

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Detalles Bibliográficos
Autores principales: An, Ming-Wen, Lu, Xin, Sargent, Daniel J., Mandrekar, Sumithra J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310446/
https://www.ncbi.nlm.nih.gov/pubmed/25649690
http://dx.doi.org/10.1155/2015/210817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310446/
https://www.ncbi.nlm.nih.gov/pubmed/25649690
http://dx.doi.org/10.1155/2015/210817

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