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The Direct Assignment Option as a Modular Design Component: An Example for the Setting of Two Predefined Subgroups
Background. A phase II design with an option for direct assignment (stop randomization and assign all patients to experimental treatment based on interim analysis, IA) for a predefined subgroup was previously proposed. Here, we illustrate the modularity of the direct assignment option by applying it...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310446/ https://www.ncbi.nlm.nih.gov/pubmed/25649690 http://dx.doi.org/10.1155/2015/210817 |