Calorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous

In laboratory yeast strains with Sir2 and Fob1 function, wild-type NAD(+) salvage is required for calorie restriction (CR) to extend replicative lifespan. CR does not significantly alter steady state levels of intracellular NAD(+) metabolites. However, levels of Sir2 and Pnc1, two enzymes that seque...

Descripción completa

Detalles Bibliográficos
Autores principales: Mei, Szu-Chieh, Brenner, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310591/
https://www.ncbi.nlm.nih.gov/pubmed/25633578
http://dx.doi.org/10.1371/journal.pbio.1002048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310591/
https://www.ncbi.nlm.nih.gov/pubmed/25633578
http://dx.doi.org/10.1371/journal.pbio.1002048

Ejemplares similares