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Calorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous
In laboratory yeast strains with Sir2 and Fob1 function, wild-type NAD(+) salvage is required for calorie restriction (CR) to extend replicative lifespan. CR does not significantly alter steady state levels of intracellular NAD(+) metabolites. However, levels of Sir2 and Pnc1, two enzymes that seque...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310591/ https://www.ncbi.nlm.nih.gov/pubmed/25633578 http://dx.doi.org/10.1371/journal.pbio.1002048 |