Cargando…

Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2

[Image: see text] The evolutionarily conserved DRY motif at the end of the third helix of rhodopsin-like, class-A G protein-coupled receptors (GPCRs) is a major regulator of receptor stability, signaling activity, and β-arrestin-mediated internalization. Substitution of the DRY arginine with histidi...

Descripción completa

Detalles Bibliográficos
Autores principales: Burczyk, Martina, Burkhalter, Martin D., Blätte, Tamara, Matysik, Sabrina, Caron, Marc G., Barak, Lawrence S., Philipp, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310627/
https://www.ncbi.nlm.nih.gov/pubmed/25555130
http://dx.doi.org/10.1021/bi501061h