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Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2
[Image: see text] The evolutionarily conserved DRY motif at the end of the third helix of rhodopsin-like, class-A G protein-coupled receptors (GPCRs) is a major regulator of receptor stability, signaling activity, and β-arrestin-mediated internalization. Substitution of the DRY arginine with histidi...
Autores principales: | Burczyk, Martina, Burkhalter, Martin D., Blätte, Tamara, Matysik, Sabrina, Caron, Marc G., Barak, Lawrence S., Philipp, Melanie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310627/ https://www.ncbi.nlm.nih.gov/pubmed/25555130 http://dx.doi.org/10.1021/bi501061h |
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