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Kinetic Mechanism for the Flipping and Excision of 1,N(6)-Ethenoadenine by AlkA
[Image: see text] Escherichia coli 3-methyladenine DNA glycosylase II (AlkA), an adaptive response glycosylase with a broad substrate range, initiates base excision repair by flipping a lesion out of the DNA duplex and hydrolyzing the N-glycosidic bond. We used transient and steady state kinetics to...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310629/ https://www.ncbi.nlm.nih.gov/pubmed/25537480 http://dx.doi.org/10.1021/bi501356x |