Notch inhibition allows oncogene independent generation of iPS cells

The reprogramming of somatic cells to pluripotency using defined transcription factors holds great promise for biomedicine. However, human reprogramming remains inefficient and relies either on the use of the potentially dangerous oncogenes KLF4 and CMYC or the genetic inhibition of the tumor suppre...

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Detalles Bibliográficos
Autores principales: Ichida, Justin K., TCW, Julia, Williams, Luis A., Carter, Ava C., Shi, Yingxiao, Moura, Marcelo T., Ziller, Michael, Singh, Sean, Amabile, Giovanni, Bock, Christoph, Umezawa, Akihiro, Rubin, Lee L., Bradner, James E., Akutsu, Hidenori, Meissner, Alexander, Eggan, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310751/
https://www.ncbi.nlm.nih.gov/pubmed/24952596
http://dx.doi.org/10.1038/nchembio.1552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310751/
https://www.ncbi.nlm.nih.gov/pubmed/24952596
http://dx.doi.org/10.1038/nchembio.1552

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