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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

In Alzheimer’s disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier with profound impact on plaque composition and toxicity. Using high-resolution confocal and in vivo t...

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Detalles Bibliográficos
Autores principales: Condello, Carlo, Yuan, Peng, Schain, Aaron, Grutzendler, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311408/
https://www.ncbi.nlm.nih.gov/pubmed/25630253
http://dx.doi.org/10.1038/ncomms7176