Cargando…
Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
In Alzheimer’s disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. Here we show that microglia constitute a barrier with profound impact on plaque composition and toxicity. Using high-resolution confocal and in vivo t...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311408/ https://www.ncbi.nlm.nih.gov/pubmed/25630253 http://dx.doi.org/10.1038/ncomms7176 |