ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1

BACKGROUND: Histone deacetylase 3 (HDAC3) is overexpressed in cancers and its inhibition enhances anti-tumor chemotherapy. ZBP-89, a transcription factor, can induce pro-apoptotic Bak and reduce HDAC3 but the mechanism is unknown. Pin1, a molecular switch that determines the fate of phosphoproteins,...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Cai Guo, Liu, Liping, Chen, George G, Tang, Xiao Lin, He, Zhiwei, He, Ming-Liang, Lai, Paul BS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311446/
https://www.ncbi.nlm.nih.gov/pubmed/25623232
http://dx.doi.org/10.1186/s12967-015-0382-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311446/
https://www.ncbi.nlm.nih.gov/pubmed/25623232
http://dx.doi.org/10.1186/s12967-015-0382-7

Ejemplares similares