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Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

Life history theory posits that the sequence and timing of events in an organism's lifespan are fine-tuned by evolution to maximize the production of viable offspring. In a virus, a life history strategy is largely manifested in its replication mode. Here, we develop a stochastic mathematical m...

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Detalles Bibliográficos
Autores principales: Schulte, Michael B, Draghi, Jeremy A, Plotkin, Joshua B, Andino, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311501/
https://www.ncbi.nlm.nih.gov/pubmed/25635405
http://dx.doi.org/10.7554/eLife.03753