Cargando…
First chemoenzymatic stereodivergent synthesis of both enantiomers of promethazine and ethopropazine
Enantioenriched promethazine and ethopropazine were synthesized through a simple and straightforward four-step chemoenzymatic route. The central chiral building block, 1-(10H-phenothiazin-10-yl)propan-2-ol, was obtained via a lipase-mediated kinetic resolution protocol, which furnished both enantiom...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311712/ https://www.ncbi.nlm.nih.gov/pubmed/25670974 http://dx.doi.org/10.3762/bjoc.10.322 |