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Three-component synthesis of C(2)F(5)-substituted pyrazoles from C(2)F(5)CH(2)NH(2)·HCl, NaNO(2) and electron-deficient alkynes
A one-pot reaction between C(2)F(5)CH(2)NH(2)·HCl, NaNO(2) and electron-deficient alkynes gives C(2)F(5)-substituted pyrazoles in excellent yields. The transformation smoothly proceeds in dichloromethane/water, tolerates the presence of air, and requires no purification of products by column chromat...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Beilstein-Institut
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311722/ https://www.ncbi.nlm.nih.gov/pubmed/25670987 http://dx.doi.org/10.3762/bjoc.11.3 |